Production of sub-10 micrometre cellulose microbeads using isoporous membranes

by E. E. Ekanem, A. Sabirova, C. Callaghan, J. L. Scott, K. J. Edler, S. P. Nunes, D. Mattia
Year: 2022 ISSN: DOI:

Extra Information

Journal of Membrane Science Letters, Volume 2, Issue 1, May 2022, 100024


The production of sub-10 μm cellulose microbeads via membrane emulsification using isoporous membranes is
reported here for the first time. Poly(ethylene terephthalate) membranes, with defined interpore distances, pore
diameters and straight-through pores were fabricated via photolithography. A dispersed phase of 8 wt% cellulose
solution was extruded through the membrane pores, forming, due to shear provided by an overhead stirrer,
cellulose solution droplets dispersed in a continuous phase composed of 2 wt% and 5 wt% Span in sunflower
oil. Upon phase inversion with ethanol, sub-10 μm microbeads with a coefficient of variation (CV) < 45 % were
produced by exploring the Weber number (Wed) - Capillary number (Cac) emulsion generation space.
These results show that sub-10 μm cellulose microbeads can be produced using isoporous polymer membranes
fabricated via photolithography, for use in a wide range of applications in the personal care, food and drug